The effect of ω-3PUFA on immune inflammation in premature infants with brain injury
Objective To analyze the clinical efficacy and its effect on immune function and cytokines of ω-3 polyunsaturated fatty acid (PUFA) in the treatment of preterm infants<32 weeks and birth weight<1500g.Methods The clinical data of preterm infants with birth gestational age<32 weeks and birth weight<1500g admitted to the neonatal intensive care unit of Ningbo Women and Children's Hospital from January 2018 to January 2023 were retrospectively analyzed,and divided into ω-3 group (n=80) and ω-6 group (n=80) according to the type of fatty acid used for treatment.ω-6 group of preterm infants were given nutritional support with ω-6PUFA,while ω-3 group of preterm infants were given nutritional support with ω-3PUFA.The efficacy,complication rate,immune function and cytokine level before and after treatment were compared between two groups.Results On the 7th day after birth,the levels of C-reactive protein,lactic acid (Lac),total bile acids,interleukin-8 (IL-8) and on the 14th day after birth,Lac,IL-8,tumor necrosis factor-α,retinopathy,and necrotizing enterocolitis complications in ω-3 group were lower than those in ω-6 group and the use of oxygen was shorter;The CD4/CD8 levels were higher in the ω-6 group.Conclusion ω-3PUFA have remarkable efficacy in nutritional support of preterm infants,which can effectively regulate immune function and inhibit the release of inflammatory factors,with fewer complications and higher safety.
万方数据
