Study on the efficacy of fluoxetine hydrochloride combined with estradiol valerate in the treatment of perimenopausal depression patients
Objective To explore the clinical efficacy of fluoxetine hydrochloride combined with estradiol valerate in the treatment of perimenopausal depression patients.Methods A total of 120 patients with perimenopausal depressive disorder admitted to Shaoxing 7th People's Hospital from January 2021 to January 2024 were selected as the study subjects.According to random number table method,the patients were divided into control group and observation group,60 cases in each group.The control group patients received estradiol valerate treatment,while the observation group patients additionally received fluoxetine hydrochloride.All patients were treated continuously for 8 weeks.At 4 weeks and 8 weeks of treatment,Hamilton depression scale (HAMD) was used to compare depression severity before and after treatment.Modified Kupperman index (KMI) was used to compare severity of menopausal symptoms before and after treatment.Changes in sex hormone levels,including follicle stimulating hormone (FSH),luteinizing hormone (LH),and estradiol (E2) were measured and compared before and after treatment.The correlation between depression severity and sex hormone levels and the severity of menopausal symptoms were evaluated using Spearman correlation analysis.Results At 4 weeks and 8 weeks of treatment,HAMD and KMI scores of observation group were significantly lower than before treatment,and lower than those of control group (P<0.05).The FSH and LH levels in both groups were significantly lower than before treatment,while E2 levels were significantly higher than before treatment (P<0.05).Spearman correlation analysis showed that HAMD score were positively correlated with KMI score,FSH level,and LH level,and negatively correlated with E2 level.Conclusion Compared with the use of estradiol valerate alone,the combination of fluoxetine hydrochloride and estradiol valerate is more effective in alleviating the severity of depression in patients with perimenopausal depression.Moreover,the severity of depression is closely related to the severity of symptoms and sex hormone levels,suggesting that this combined treatment regimen has broader applicability for patients with perimenopausal depression.
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