目的 探讨青少年双相障碍(bipolar disorder,BD)抑郁发作患者的大脑灰质体积(gray matter volume,GMV)变化.方法 选取2019年9月至2021年12月于西湖大学医学院附属杭州市第一人民医院接受磁共振成像(magnetic resonance imaging,MRI)人工视觉检查的36例BD患者(BD组)和37名健康体检者(HC组),通过FreeSurferv6.0.0处理结构MRI数据,并使用SPSS 26.0及R语言软件进行统计分析.采用受试者操作特征曲线(receiver operating characteristic curve,ROC曲线)评估各脑区的诊断效能.结果 与HC组比较,BD组患者的右侧额上回、右侧伏隔核、左侧岛叶、右外侧眶额叶和右内侧眶额叶的GMV显著减小(P＜0.05).ROC曲线分析显示右侧额上回和右侧伏隔核的ROC曲线下面积(area under the curve,AUC)分别为0.739和0.712,联合多个脑区的AUC为0.820.结论 青少年BD患者存在特定脑区GMV显著减小,可为BD的早期识别和病理机制研究提供参考.
Analysis of brain gray matter volume alterations in adolescents with bipolar disorder
Objective To explore the alterations in gray matter volume(GMV)in adolescents with bipolar disorder(BD).Methods 36 BD patients(BD group)and 37 healthy controls(HC group)who underwent magnetic resonance imaging(MRI)for artificial visual inspection in Affiliated Hangzhou First People's Hospital,School of Medicine,Westlake University from September 2019 to December 2021 were selected.Structural MRI data were processed by using FreeSurferv6.0.0,and statistical analysis were conducted by using SPSS 26.0 and R language software.Receiver operating characteristic(ROC)curve were employed to assess the diagnostic efficacy of various brain regions.Results Compared to HC group,patients in BD group exhibited significant reductions in GMV in the right superior frontal gyrus,right nucleus accumbens,left insula,right lateral orbitofrontal cortex,and right medial orbitofrontal cortex(P＜0.05).ROC curve analysis indicated that area under the curve(AUC)for the right superior frontal gyrus and right nucleus accumbens were 0.739 and 0.712 respectively,while the combined AUC for multiple brain regions was 0.820.Conclusion Adolescents with BD show significant reductions in GMV in specific brain regions,provide reference for the early identification and pathological mechanism research of BD.
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