目的 探讨绝经后女性血清miR-27b-3p与Ⅰ型前胶原氨基端前肽(N-terminal propeptide of type Ⅰ procollagen,PINP)和Ⅰ型胶原C末端肽1(C-terminal telopeptide of type Ⅰ collagen 1,CTX-1)的相关性.方法 选取2022年2月至2023年2月于浙江中医药大学附属第二医院就诊的49例绝经后骨质疏松患者为研究对象,根据测得T值将其分为骨质疏松(osteoporosis,OP)组(T≤-2.5SD,26例)和骨量减少(osteopenia,OPn)组(-2.5SD<T<-1.0SD,23例).检测并比较两组患者的血清miR-27b-3p、PINP、CTX-1表达水平,分析血清P1NP和CTX-1与miR-27b-3p的相关性.结果 OP组患者的血清miR-27b-3p、PINP/CTX-1水平均显著低于OPn组,PINP和CTX-1水平均显著高于OPn组(P<0.05);Pearson分析结果显示,血清PINP和CTX-1水平与miR-27b-3p均呈负相关(P<0.05),PINP/CTX-1与miR-27b-3p呈正相关(P<0.05).结论 血清miR-27b-3p水平可作为绝经后女性骨形成的潜在标志物.
Expression and significance of serum miR-27b-3p in patients with postmenopausal osteoporosis
Objective To investigate the correlation between serum miR-27b-3p and N-terminal propeptide of type Ⅰ procollagen (PINP) and C-terminal telopeptide of type Ⅰ collagen 1 (CTX-1) in postmenopausal women. Methods Forty-nine patients with postmenopausal osteoporosis treated in the Second Affiliated Hospital,Zhejiang Chinese Medical University from February 2022 to February 2023 were selected as study objects. They were divided into osteoporosis (OP) group (T≤-2.5SD,26 cases) and osteopenia (OPn) group (-2.5SD<T<-1.0SD,23 cases). The expression levels of serum miR-27b-3p,PINP and CTX-1 in two groups were detected and compared,and the correlation between serum P1NP and CTX-1 and miR-27b-3p was analyzed. Results The levels of serum miR-27b-3p and PINP/CTX-1 in OP group were significantly lower than those in OPn group,and the levels of PINP and CTX-1 were significantly higher than those in OPn group (P<0.05). Pearson analysis showed that serum PINP and CTX-1 levels were negatively correlated with miR-27b-3p (P<0.05),while PINP/CTX-1 was positively correlated with miR-27b-3p (P<0.05). Conclusion Serum miR-27b-3p levels may serve as a potential marker for bone formation in postmenopausal women.
miR-27b-3pBone metabolismPostmenopausal osteoporosisN-terminal propeptide of type Ⅰ procollagenC-terminal telopeptide of type Ⅰ collagen 1
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