Objective To evaluate function of human neutrophil peptides(HNPs)for the severity and prognosis of patients with acute respiratory distress syndrome(ARDS).Methods From December 2021 to December 2023,80 ARDS patients were enrolled in the study from the intensive care unit(ICU)of Shenzhen Qianhai Shekou Free Trade Zone Hospital.Plasma samples were taken within 24 hours after admission to ICU,HNPs concentration was then measured with enzyme-linked immunesorbent assay.Differences in HNPs concentration and acute physiology and chronic health evaluation-Ⅱ(APACHE Ⅱ)score etc.Clinical index parameters were compared in survival group(n=48)and death group(n=32)based on their 28-day outcomes.The correlation between HNPs concentration and APACHE Ⅱ score were calculated by Spearman correlation analysis.We analyzed the risk factors for 28 days death of ARDS patients by single-factor Logistic regression,then used the significant risk factors to analyze death odds ratio by multivariate Logistic regression analysis.Results HNPs concentration and APACHE Ⅱ score of death group was significantly increased than those of survival group(P<0.001).HNPs concentration has a positive correlation with APACHE Ⅱ score(r=0.344,P<0.001).HNPs and APACHE Ⅱ were independent prognosis factor of 28-day mortality of ARDS patients.Conclusion Plasma HNPs concentration may be early used to evaluate the severity and prognosis of ARDS patients.
关键词
急性呼吸窘迫综合征/人中性粒细胞多肽/急性生理和慢性健康状况Ⅱ评分/预后
Key words
Acute respiratory distress syndrome/Human neutrophil peptides/Acute physiology and chronic health evaluation-Ⅱ score/Prognosis
万方数据