Correlation between thyroid-related serological indexes and clinicopathological features of papillary thyroid cancer
Objective To explore the correlation between preoperative thyroid-related serological indicators[including thyroid stimulating hormone(TSH),thyroglobulin(Tg),anti-thyroglobulin antibody(TGAb),thyroid peroxidase antibody(TPOAb)and thyrotropin receptor antibody(TRAb)]and the clinicopathological features of papillary thyroid cancer.Methods The clinical data of 272 patients with papillary thyroid cancer who underwent surgery in Guizhou Provincial People's Hospital from January to December 2020 were retrospectively analyzed,and the relationship between the clinicopathological characteristics of papillary thyroid cancer patients and preoperative thyroid-related serological indicators was compared.Results The incidence of BRAF gene V600E mutation in the low TSH×TRAb group was lower than that in the high TSH×TRAb group,and the difference was statistically significant(P<0.01);Tumor size of patients in the low Tg×TGAb group was lower than that in the high Tg×TGAb group,the metastasis rate in the lateral cervical region was lower than that in the high Tg×TGAb group,and the incidence of BRAF gene V600E mutation was lower than that in the high Tg×TGAb group,and the difference was all statistically significant(P<0.05);The incidence of BRAF gene V600E mutation in the low TGAb/TPOAb group was significantly lower than that in the high TGAb/TPOAb group(P<0.05).Receiver operating characteristic(ROC)curve analysis showed that the preoperative TSH×TRAb value guided the diagnosis of BRAF gene V600E mutation in papillary thyroid cancer(with sensitivity was 61.3%,specificity was 71.7%),followed by TGAb/TPOAb value(with sensitivity was 39.2%,specificity was 76.1%),and finally Tg×TGAb(with sensitivity was 60.9%,specificity was 53.9%);The sensitivity and specificity of preoperative Tg×TGAb value in guiding tumor size of papillary thyroid cancer was 61.6%and 64.7%respectively.The sensitivity and specificity of preoperative Tg×TGAb value in guiding lateral cervical region metastasis of papillary thyroid cancer was 60.0%and 73.5%respectively.Conclusion Preoperative TSH×TRAb,Tg×TGAb,and TGAb/TPOAb values are independent risk factors for BRAF geneV600E mutation in Papillary thyroid cancer,and have certain diagnostic value for BRAF gene V600E mutation in papillary thyroid cancer.Preoperative Tg×TGAb value has certain diagnostic value for tumor size and lateral cervical metastasis of papillary thyroid cancer,which is helpful to evaluate the development and prognosis of papillary thyroid cancer.
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