Analysis of medication patterns and pharmacological mechanisms for treating insomnia based on data mining and network pharmacology
Objective Using data mining to analyze the medication patterns for treating insomnia,and applying network pharmacology to preliminarily analyze the mechanisms of drugs.Methods The prescriptions for the treatment of insomnia by Liang Hui from August 2022 to September 2023 were collected.A database was constructed using tools such as Excel software and the Traditional Chinese Medicine Inheritance Auxiliary Platform.The drugs were analyzed for frequencies,natures,drug associations,and clustering were analyzed.Core drug components and disease targets were retrieved,and the target genes for the treatment of insomnia were subjected to gene ontology and Kyoto Encyclopedia of Genes and Genomes analysises.Results A total of 300 insomnia-related prescriptions were collected,involving 96 flavors of drugs.The drug nature was mainly cold,and the drug flavor was mainly bitter.The core herbal combinations included Radix Bupleuri,Poria,Atractylodis Macrocephala,Radix Paeoniae Alba,Radix Curcumae,Fructus Gardeniae,Anemarrhenae,Poria cum Radix Pini,Sedum aizoon L.Critical drug targets for the treatment of insomnia encompassed albumin,serine/threonine kinase 1,epidermal growth factor receptor,B-cell lymphoma-2,estrogen receptor 1,cysteinyl aspartate specific proteinase-3,among others;The main enriched pathways included cancer pathway,lipid and atherosclerosis pathway,phosphoinositide 3-kinase(PI3K)/protein kinase B(PKB,also known as Akt)signaling pathway,Kaposi sarcoma-associated herpesvirus infection pathway,hypoxia-inducible factor-1(HIF-1)signaling pathway,etc.;The main biological processes included cell apoptosis,response to nicotine,mitogen-activated protein kinase cascade reactions,etc..Conclusion Liang Hui's treatment of insomnia follows the principle of treating symptoms with the same root cause,focusing on Qingli Sanjiao,regulating liver and strengthening spleen,smoothing the qi and organs,supplementes by nourishing the heart and calming the nerves,forming a core prescription integrating Radix Bupleuri,Poria,Rhizoma Atractylodis Macrocephalae,Radix Paeoniae Alba,Radix Curcumae,Fructus Gardeniae,Rhizoma Anemarrhenae,Poria cocos,Sedum aizoon L.Its pathways are related with PI3K/AKT,HIF-1 and so on.
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