首页|人参有效成分抗疲劳作用机制的研究进展

人参有效成分抗疲劳作用机制的研究进展

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人参不仅是我国传统珍贵的中药材，更是食疗保健佳品，具有多方面抗疲劳作用。人参抗疲劳的主要活性成分包括人参多糖、寡肽和皂苷，可能通过调节糖类代谢、激活磷脂酰肌醇-3-羟激酶(PI3K)/蛋白激酶B(Akt)/哺乳动物雷帕霉素靶蛋白(mTOR)等信号通路、提高骨骼肌线粒体供能效力和加快自由基清除从而产生抗疲劳作用。综述人参多糖、蛋白质、人参皂苷类有效成分抗疲劳药理作用机制，旨在为人参用于各类抗疲劳功能产品的开发应用提供依据。
Research progress of anti-fatigue mechanism of active components of ginseng
Ginseng is not only a precious traditional Chinese medicinal herb in China,but also a great food therapy and health product,with various anti fatigue effects.The main active ingredients of ginseng in anti fatigue include ginseng polysaccharides,oligopeptides,and saponins,which may regulate carbohydrate metabolism,activate phosphatidylinositol 3-hydroxykinase(PI3K)/protein kinase B(Akt)/mammalian target of rapamycin(mTOR)and other signaling pathways enhance the energy supply efficiency of skeletal muscle mitochondria and accelerate the clearance of free radicals,thereby producing an anti fatigue efect.Summarize the anti fatigue pharmacological mechanisms of ginseng polysaccharides,proteins,and ginsenosides,aiming to provide a basis for the development and application of ginseng in various anti fatigue functional products.

ginseng polysaccharidesginseng protein and ginsenosideanti fatiguephosphatidylinositol 3-hydroxykinase(PI3K)protein kinase B(Akt)mammalian rapamycin target protein(mTOR)

郑怡菲、李涛、赵余庆

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延边大学药学院,吉林延吉 133002

延边大学长白山天然药物研究教育部重点实验室,吉林延吉 133002

人参多糖 人参蛋白质、人参皂苷 抗疲劳 磷脂酰肌醇-3-羟激酶(PI3K) 蛋白激酶B(Akt) 哺乳动物雷帕霉素靶蛋白(mTOR)

2023

10.7501/j.issn.1674-6376.2023.11.028

药物评价研究
天津药物研究院 中国药学会

药物评价研究

CSTPCD北大核心
影响因子：1.199
ISSN：1674-6376
年,卷(期)：2023.46(11)
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