Differences in safety and efficacy of levosalbutamol and salbutamol combined with ipratropium bromide and beclomethasone in patients with acute exacerbation of chronic obstructive pulmonary disease
Objective To explore the differences in safety and efficacy between levosalbutamol and salbutamol in combination with ipratropium bromide and beclomethasone for patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods A randomized controlled,single center,prospective study method was used to select 100 hospitalized AECOPD patients who visited the Department of Respiratory Medicine of the Second People's Hospital of Hefei from January 1,2022 to December 31,2022 as the study subjects.PASS 26.0 software was used to randomly divide them into a control group(n=50)and an experimental group(n=50).Patients in the control group were treated with nebulized inhalation of salbutamol,ipratropium bromide,and beclomethasone,while patients in the experimental group were treated with nebulized inhalation of levosalbutamol,ipratropium bromide,and beclomethasone.The changes in clinical indicators and incidence of adverse reactions before and after treatment were compared between the two groups of patients.Results The total effective rate of the experimental group(95.65％)was higher than that of the control group(84.00％),and the difference was statistically significant(P＜0.05).24 hour sputum volume,blood gas analysis indicators[arterial oxygen partial pressure(paO2),arterial carbon dioxide partial pressure(paCO2),arterial oxygen saturation(SaO2)],lung function indicators(FEV1,FVC,FEV1/FVC),serum inflammatory factor indicators(hs-CRP,IL-8,TNF-α)in the two groups before treatment.The comparison of oxidative stress response indicators(MDA,GSH-Px,SOD)showed no statistically significant difference(P＞0.05).After treatment,the 24-hour sputum volume,paCO2,chronic obstructive pulmonary disease acute exacerbation recognition tool(CERT)score,MDA,hs-CRP,IL-8,TNF-α in both groups.All decreased compared to before treatment in same group,while paO2,FEV1,FVC,FEV1/FVC,GSH-Px,SOD significantly increased compared to before treatment in same group,and the differences were statistically significant(P＜0.05).After treatment,the improvement of various indicators in the experimental group was significantly higher than that in the control group(P＜0.05).During the treatment process,the control group tolerated well and did not experience any significant adverse reactions.There were two cases of headache,one case of rash,and one case of diarrhea in the experimental group.The incidence of adverse reactions between the two groups was statistically different(P＜0.05).Conclusion The clinical efficacy of the triple drug regimen with the addition of levosalbutamol in the treatment of AECOPD patients is better than that of the triple drug regimen with salbutamol,but the incidence of adverse reactions is higher.Clinical application needs to pay attention to its safety.
NETL
NSTL
万方数据
维普
