Meta-analysis of Dan'e Fukang Decoction in treatment of endometriosis
Objective To evaluate the efficacy and safety of Dan'e Fukang Decoction in the treatment of endometriosis(EMs).Methods Databases such as CNKI,Wangfang Data,VIP,SinoMed,PubMed,Cochrane Library and Web of Science were searched by computer for randomized controlled trials(RCT)of Dan'e Fukang Decoction in the treatment of EMs from database establishment to September 3,2023.After literature screening,evaluate literature quality by Cochrane information extraction and deviation risk included in the evaluation study,Meta-analysis was performed using RevMan 5.4.1 software.Results A total of 21 RCTs were included.Meta-analysis showed that Dan'e Fukang Decoction was superior to gastronome in the clinical response rate of Ems[RR=1.07,95％CI(1.01,1.13),P=0.01],pain visual analogue scale(VAS)score[MD=-1.59,95％CI(-2.70,-0.47),P=0.005],serum cancer antigen CA125 level[MD=-5.91,95％CI(-8.85,-2.97),P＜0.000 01],and the differences were statistically significant;Dan'e Fukang Decoction was superior to mifepristone in the clinical response rate of Ems[RR=1.23,95％CI(0.91,1.65),P=0.18].The incidence of adverse events in EMs treated with Dan'e Fukang Decoction alone[MD=0.18,95％CI(0.10,0.32),P＜0.000 001]was lower than that with gestrinone alone,and the difference was statistically significant.Conclusion Dan'e Fukang Decoction has good efficacy and safety in the treatment of EMs.
NETL
NSTL
万方数据
维普
