Study on dosage pattern of Chinese herbal medicine compound for ulcerative colitis based on national patent
Objective To summarize and summarize the rules of compounding and the development trend of medication through systematic analysis of national Chinese medicine compounding patents for the treatment of ulcerative colitis.Methods The data of Chinese herbal compound patents for the treatment of ulcerative colitis were retrieved from the Chinese patent publication website of the State Intellectual Property Office.SPSS Statistic 26.0 and SPSS Modeler 15.0 were used to analyze high-frequency traditional Chinese medicines(frequency ≥ 20)for sexual flavor,attribution and efficacy,as well as systematic clustering,Apriori association rules and network analysis.Cytoscape 3.7.2 was used to construct the core complex network of traditional Chinese medicine.Constructing a highly interconnected subnetwork of rare Chinese medicinal herbs using Cytoscape 3.7.2 to unveil novel drug combinations.Results A total of 147 herbal compound patents for the treatment of ulcerative colitis were included from the establishment of the database to August 31,2023,involving 500 herbal medicines and 20 high-frequency herbal medicines,including Glycyrrhizae Radix et Rhizoma(60 times,40.82％),Coptidis Rhizoma(56 times,38.10％)and Astragali Radix(46 times,31.29％),with bitter taste being the most common and cold and warm properties,mostly attributed to the spleen meridian.Heat-clearing drugs and tonic drugs were mostly used.Cluster analysis yielded four groups of herbal combinations(new prescriptions),mainly"Coptidis Rhizoma,Aucklandiae Radix,Paeoniae Radix Alba,Angelicae Sinensis Radix,Glycyrrhizae Radix et Rhizoma,Citri Reticulatae Pericarpium,Scutellariae Radix,Bupleuri Radix,Poria and Coicis Semen".Commonly used pairs include Aucklandiae Radix-Coptidis Rhizoma(support 21.77％,confidence 71.88％),etc.Commonly used corner drug combinations include Paeoniae Radix Alba-Coptidis Rhizoma-Glycyrrhizae Radix et Rhizoma(support 14.97％,confidence 72.73％),etc.The potential prescriptions were"Eclipta prostrata-Dendrobium nobile-Citrus aurantium-Citrus reticulata-Epimedium brevicornum",etc.Conclusion The treatment of ulcerative colitis with national herbal compound patent is commonly used to clear heat and detoxify the toxins and benefit the qi and spleen,which is in line with the clinical treatment principle of ulcerative colitis.Refractory or severe ulcerative colitis can be considered as a combination of attacking and tonifying method,with appropriate addition of worm-like drugs that activate blood circulation and remove blood stasis.
ulcerative colitisnational patentchinese herbal compoundthe rule of combinationdevelopment tendencyCoptidis RhizomaAucklandiae RadixPaeoniae Radix Alba-Coptidis Rhizoma-Glycyrrhizae Radix et Rhizoma
NETL
NSTL
万方数据
维普
