网络毒理学在中药安全性评价中的研究现状与发展思考
Research status and development thinking of network toxicology in safety evaluation of traditional Chinese medicine
申佰轩 1郭康雅 2郭源辉 1孔娇 3刘传鑫1
作者信息
- 1. 河南科技大学临床医学院,河南科技大学第一附属医院内分泌代谢中心,河南省罕见病重点实验室,河南洛阳 471003
- 2. 北京中医药大学中药学院,北京 100029
- 3. 浙江大学药学院药物代谢和药物分析研究所,浙江杭州 310058
- 折叠
摘要
针对现阶段的网络毒理学研究,系统梳理了网络毒理学在中药安全性研究中的方法特点,实践应用及发展现状,总结了网络毒理学的研究方法与依托工具,对网络毒理学在预测中药不良结局、毒性机制分析、有害成分预判、多学科交叉运用、组学技术联用等方面进行分析归纳.重点关注当前网络毒理学存在的不足与短板,并提出初步的解决策略与完善方案以供同仁参考、批评和借鉴,以期为促进网络毒理学进一步发展及中药安全性评价的构建提供参考.
Abstract
In view of the current stage of network toxicology research,the characteristics,practical application and development status of network toxicology in the safety research of traditional Chinese medicine were systematically reviewed.The research methods and supporting tools of network toxicology were summarized.The network toxicology was used to predict the adverse outcomes of traditional Chinese medicine,toxicity mechanism analysis,harmful component prediction,multidisciplinary cross-application,and omics technology.Focus on the shortcomings of current network toxicology and put forward preliminary solutions and improvement plans for colleagues to refer,criticize and learn.In order to provide reference for promoting the further development of network toxicology and the construction of safety evaluation of traditional Chinese medicine.
关键词
中药/毒性机制/中药安全/网络毒理学/不良结局预测/组学技术Key words
Traditional Chinese medicine/toxic mechanism/safety of traditional Chinese medicine/network toxicology/adverse outcome prediction/omics technology引用本文复制引用
基金项目
国家自然科学基金资助项目(82204938)
出版年
2024
NETL
NSTL
维普
万方数据