首页|乌药提取物及有效成分抗肝损伤的药理作用研究进展

乌药提取物及有效成分抗肝损伤的药理作用研究进展

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乌药为樟科山胡椒属植物乌药Lindera aggregata(Sims)Kosterm.的干燥块根,主要成分包括倍半萜类、生物碱类、黄酮类和挥发油等,具有抗氧化、抑菌、抗炎镇痛、抗肿瘤等多种药理作用.近年,诸多研究表明乌药对酒精性肝损伤、化学性肝损伤、免疫性肝损伤、糖尿病合并肝损伤、脂肪肝、肝癌等肝脏相关疾病都有防治作用.综述了乌药水提取物、醇提取物、醇提取物的萃取物、叶提取物、根挥发油及乌药醚内酯抗肝损伤的药理作用及研究现状,以期为后续乌药相关保肝药物的开发及利用提供理论基础.
Research progress on anti-hepatic injury effects of extracts of Lindera aggregata and its active components
Lindera aggregata was the dried root tubers of Lindera aggregata(Sims)Kosterm.The main components include sesquiterpenoids,alkaloids,flavonoids and volatile oils,which have various pharmacological effects such as antioxidant,antibacterial,anti-inflammatory and analgesic,and anti-tumour.In recent years,many studies have shown that Lindera aggregata has been effective against alcoholic liver injury,chemical liver injury,immune liver injury,diabetes combined with liver injury,fatty liver,liver cancer and other liver-related diseases.This article reviewed the pharmacological effects on liver injury and research status of water extract,alcohol extract,various extracts of alcohol extract,leaf extract,volatile oil of Lindera aggregata and linderane,providing a theoretical basis for the subsequent development and utilization of Lindera aggregata related drugs.

Lindera aggregata(Sims)Kostermlinderaneliver injuryfatty liverliver cancermechanism

欧阳婷、刘涛、欧阳林旗

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湖南中医药大学第一附属医院,湖南长沙 410007

长沙市第一医院,湖南长沙 410005

湖南中医药大学药学院,湖南长沙 410208

乌药 乌药醚内酯 肝损伤 脂肪肝 肝癌 作用机制

湖南省自然科学基金资助项目湖南省卫生健康委科研项目湖南省卫生健康委科研项目湖南中医药大学校级科研基金湖南中医药大学校级科研基金湖南中医药大学校级科研基金湖南省"十四五"中医重点专科资助项目

2020JJ5434C202313057956D2023020488062019XJJJ0332021XJJJ0402022XYLH004湘中医药函[2023]4号

2024

10.7501/j.issn.1674-6376.2024.01.024

药物评价研究
天津药物研究院 中国药学会

药物评价研究

CSTPCD北大核心
影响因子：1.199
ISSN：1674-6376
年,卷(期)：2024.47(1)
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