摘要
乌药为樟科山胡椒属植物乌药Lindera aggregata(Sims)Kosterm.的干燥块根,主要成分包括倍半萜类、生物碱类、黄酮类和挥发油等,具有抗氧化、抑菌、抗炎镇痛、抗肿瘤等多种药理作用.近年,诸多研究表明乌药对酒精性肝损伤、化学性肝损伤、免疫性肝损伤、糖尿病合并肝损伤、脂肪肝、肝癌等肝脏相关疾病都有防治作用.综述了乌药水提取物、醇提取物、醇提取物的萃取物、叶提取物、根挥发油及乌药醚内酯抗肝损伤的药理作用及研究现状,以期为后续乌药相关保肝药物的开发及利用提供理论基础.
Abstract
Lindera aggregata was the dried root tubers of Lindera aggregata(Sims)Kosterm.The main components include sesquiterpenoids,alkaloids,flavonoids and volatile oils,which have various pharmacological effects such as antioxidant,antibacterial,anti-inflammatory and analgesic,and anti-tumour.In recent years,many studies have shown that Lindera aggregata has been effective against alcoholic liver injury,chemical liver injury,immune liver injury,diabetes combined with liver injury,fatty liver,liver cancer and other liver-related diseases.This article reviewed the pharmacological effects on liver injury and research status of water extract,alcohol extract,various extracts of alcohol extract,leaf extract,volatile oil of Lindera aggregata and linderane,providing a theoretical basis for the subsequent development and utilization of Lindera aggregata related drugs.
基金项目
湖南省自然科学基金资助项目(2020JJ5434)
湖南省卫生健康委科研项目(C202313057956)
湖南省卫生健康委科研项目(D202302048806)
湖南中医药大学校级科研基金(2019XJJJ033)
湖南中医药大学校级科研基金(2021XJJJ040)
湖南中医药大学校级科研基金(2022XYLH004)
湖南省"十四五"中医重点专科资助项目(湘中医药函[2023]4号)
NETL
NSTL
维普
万方数据