Research progress on pharmacokinetics of dehydroevodiamine
Dehydroevodiamine is a main active ingredient from Euodia rutaecarpa.As an indoline-quinazolone alkaloid,its pharmacological effects include anti-tumor,anti-arrhythmia,anti-inflammatory,antiviral,especially in anti-Alzheimer's disease.Dehydroevodiamine could easily cross the blood-brain barrier and act on central nervous system.Its drug time curve showed a bimodal phenomenon,and metabolic pathways are summarized such as hydroxylation,demethylation and conjugation with glucuronic acid.The pharmacokinetics research progress on absorption,distribution,metabolism and excretion of dehydroevodiamine,and dehydroevodiamine in Euodia rutaecarpa and its preparations,were reviewed,and the pharmacokinetic characteristics were summarized,so as to provide reference for the clinical application,further development and application of dehydroevodiamine.
dehydroevodiamineindoline-quinazoloneEuodia rutaecarpapharmacokineticsblood-brain barrierdrug time curve
NETL
NSTL
万方数据
维普
