Clinical comprehensive evaluation of Kushen Gel(Kunlishu?)in treatment of vulvovaginal candidiasis(dampness-heat syndrome)
Objective To evaluate the clinical effect of Kushen Gel(Kunlishu®)on vulvovaginal candidiasis(damp-heat syndrome).Method This study through the system combing Kushen Gel(Kunlishu®)treating vulvovaginal candidiasis(dampness-heat syndrome)of existing research,using the combination of qualitative and quantitative evaluation method,based on multiple criteria decision making(MCDA)model,the application of CSC v2.0,the clinical comprehensive evaluation of Kushen Gel(Kunlishu®)was carried out from the dimension of"6+1".Results Kushen Gel(Kunlishu®)has carried out self-reporting system(SRS)monitoring data,RCT,real world studies,Meta-analysis and non-clinical safety studies.No serious adverse reactions have been found,and its safety is rated as GRADE A.Meta-analysis showed that the combined use of Kushen Gel(Kunlishu®)and antifungal drugs(fluconazole capsules,clotrimazole vaginal tablets,clotrimazole vaginal effervescent tablets,ketoconazole tablets)was superior to antifungal drugs in terms of candida negative conversion rate,recurrence rate and clinical symptom improvement time,and the effectiveness was rated as GRADE A.According to the analysis of incremental effect level,the treatment plan of Kushen Gel(Kunlishu®)combined with clotrimazole vaginal tablet was more economical by decision tree model.However,due to the availability of data,this study only calculated direct medical costs,which is rated B for economy.Kushen Gel(Kunlishu®)combined with antifungal drugs can significantly reduce the recurrence rate of VVC,which is the first vaginal carpod gel in China(patent no.ZL031151981),rated as B grade for innovation.Generally,there is no need for individual treatment plan,the supply,storage and transportation are relatively convenient,and the policy publicity and promotion information and drug information are standardized,which are easy to operate for doctors and patients.Chinese patent medicine information is complete,in line with the provisions of national standards,relatively standardized,accurate,Suitability rated as B.The price of drugs is medium,with good affordability and availability.Rated B for accessibility.It comes from the Golden Chamber synopsis,and people are experienced in using it.Chinese medicine features rated B.Conclusion Based on the"6+1"dimension,the CSC V2.0 software was used to calculate the clinical value of Kushen Gel(Kunlishu®),and it was suggested that it could be translated directly into relevant policy results of basic clinical medication management according to the program.
Kushen Gel(Kunlishu®)vulvovaginal candidiasisconversion rate of candida to negativeclinical comprehensive evaluationmulti-criteria decision analysis
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NSTL
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