Clinical study of Qingke Pingchuan Granules combined with amoxicillin in treatment of adult patients with acute bronchitis
Objective To explore the clinical efficacy of Chinese patent medicine Qingke Pingchuan Granules combined with amoxicillin in treatment of adult patients with acute bronchitis.Methods A total of 93 patients with acute bronchitis treated in Suqian Traditional Chinese Medicine Hospital from March 2022 to January 2023 were divided into control group(n=45)and experimental group(n=48).Patients in the control group were given Amoxicillin Capsule,0.5 g once time,three times once day.On the basis of the control group,patients in the experimental group were added with Qingke Pingchuan Granules,10 g once time,three times once day.All patients were treated for seven days.The clinical efficacy,TCM syndrome score,clinical symptom disappearance time,cough degree score,serum inflammatory factor level before and after treatment of the two groups were observed,and the differences between the two groups were compared.Results The total effective rate of the experimental group(97.92％)was significantly higher than that of the control group(87.67％)(P＜0.05).Traditional Chinese medicine syndrome scores(cough,expectoration,phlegm sounds,and wheezing)of patients in two groups were reduced,the disappearance time of clinical symptoms(cough,expectoration,and wheezing)were shortened(P＜0.05),cough severity CET scores and serum inflammatory factor levels[interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),high sensitivity C-reactive protein(hs-CRP),calcitonin(PCT)]were reduced significantly(P＜0.05),and effect of the experimental group was significantly stronger than the control group(P＜0.05).In addition,the TCM syndrome score of wheezing in the experimental group was significantly improved(P＜0.05).Conclusion Qingke Pingchuan Granules combined with amoxicillin is effective in treatment of acute bronchitis.It can significantly improve the clinical effective rate,improve the clinical symptoms,shorten the course of the disease,improve the inflammatory response,and has the value of clinical application
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