Advances in mechanism of specific transport of aristolochic acid in renal tubular epithelial cells
Acute and chronic nephritis characterised by progressive interstitial fibrosis caused by ingestion of aristolochic acid Ⅰthrough misapplication or dietary contamination is known as aristolochic acid nephropathy or Balkan endemic nephropathy.Aristolochic acid Ⅰ specifically damages the proximal tubules,while it does not show any significant direct damaging effect on other tissue cells of the kidney.Therefore,the specific uptake of aristolochic acid Ⅰ by proximal tubular epithelial cells via organic anionic proteins 1 and 3 is the key to the specific nephrotoxic effects of aristolochic acid Ⅰ.The mechanism of renal tubular uptake of aristolochic acid Ⅰ has been clarified in recent years,but the proteins involved in its transport on the apical side of renal tubular epithelial cells have rarely been reported.By reviewing the mechanism of aristolochic acid Ⅰ elimination in renal tubules,we hope to provide new targets for the prevention and treatment of aristolochic acid nephropathy.
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