Research progress on structural modifications of indole derivatives and anti-breast cancer effects
Indole,a planar heterocyclic molecule,plays an important role in drug design due to its extensive anti-cancer activity against breast cancer,lung cancer and colon cancer.In this paper,the structure modification of indole-3-methanol(I3C)and its metabolite 3,3'-diindolemethane(DIM),the structure modification of indole skeleton structure,the structure modification of oxidized indole derivatives and azaindole derivatives were studied.In addition,the effects of indole derivatives on Luminal type breast carcinoma,human epidermal growth factor receptor 2(HER-2)overexpression type breast carcinoma and triple negative breast cancer(TNBC)were summarized.The anti-breast cancer effects of indole derivatives were systematically reviewed from the aspects of cell level,breast cancer-related proteins,receptors,classical pathways,establishment of pharmacological models in vivo and in vitro,and changes of related indexes,to provide theoretical basis for the research of indole derivatives in the field of anti-breast cancer drug innovation.
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