纳米氧化锌抗血液肿瘤的药理作用及机制研究进展
Research progress on pharmacological action and mechanism of nano-zinc oxide against hematological tumors
韩晨 1吕纯懿 1王腾 1李宗宏 1王文浩 1徐瑞荣2
作者信息
- 1. 山东中医药大学,山东济南 250014
- 2. 山东省卫健委中西医结合血液学重点实验室,山东中医药大学血液病研究所,山东中医药大学附属医院血液病科,山东济南 250014
- 折叠
摘要
纳米氧化锌(ZnO-NPs)是直径在1～100 nm的无机材料,具有靶向肿瘤细胞、对血液肿瘤细胞敏感的特性,而对正常细胞影响较小,在治疗血液肿瘤方面逐渐成为研究热点.ZnO-NPs通过阻滞细胞周期、抑制肿瘤细胞增殖、调控线粒体功能、通过释放Zn2+来影响细胞稳态等进而诱导肿瘤细胞凋亡,从而破坏肿瘤细胞稳态;还可增敏化疗药物,并作为生物传感器,在治疗血液肿瘤方面具有很大潜力.对ZnO-NPs的药理作用及其在抗白血病、多发性骨髓瘤、淋巴瘤中的药理机制进行综述,以期为优化血液肿瘤治疗手段提供新策略.
Abstract
Nano-zinc oxide(ZnO-NPs)is an inorganic material with a diameter of 1-100 nm,which has the characteristics of targeting tumor cells and being sensitive to blood tumor cells,but has little influence on normal cells,and has gradually become a research hotspot in the treatment of blood tumors.ZnO-NPs induces apoptosis by blocking cell cycle,inhibiting the proliferation of tumor cells,regulating mitochondrial function,and releasing Zn2+to affect cell homeostasis,thus destroying the homeostasis of blood tumor cells.It can sensitize chemotherapy drugs and can be used as a biosensor,which has great potential in the treatment of blood tumors.The pharmacological effects of ZnO-NPs and its mechanism in leukemia,multiple myeloma and lymphoma were reviewed in order to provide new strategies for optimizing treatment methods.
关键词
纳米氧化锌/血液肿瘤/靶向肿瘤细胞/细胞周期/线粒体/细胞稳态Key words
nano-zinc oxide(ZnO-NPs)/hematological tumor/targeting tumor cells/cell cycle/mitochondria/cell homeostasis引用本文复制引用
基金项目
山东省自然科学基金资助项目(ZR2020KH023)
出版年
2024
NETL
NSTL
万方数据