Research progress on pharmacological action and mechanism of nano-zinc oxide against hematological tumors
Nano-zinc oxide(ZnO-NPs)is an inorganic material with a diameter of 1-100 nm,which has the characteristics of targeting tumor cells and being sensitive to blood tumor cells,but has little influence on normal cells,and has gradually become a research hotspot in the treatment of blood tumors.ZnO-NPs induces apoptosis by blocking cell cycle,inhibiting the proliferation of tumor cells,regulating mitochondrial function,and releasing Zn2+to affect cell homeostasis,thus destroying the homeostasis of blood tumor cells.It can sensitize chemotherapy drugs and can be used as a biosensor,which has great potential in the treatment of blood tumors.The pharmacological effects of ZnO-NPs and its mechanism in leukemia,multiple myeloma and lymphoma were reviewed in order to provide new strategies for optimizing treatment methods.
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