Research advances on antidepressant effects and their mechanism of magnolol and honokiol
In animal experiments magnolol and honokiol have the pharmacologic effects in prevention and treatment for acute and chronic depression.Their basic mechanisms are antioxidation and anti-inflammation:by scavenging direct free radial and eliminating indirect free radial through up-regulating Nrf2 anti-oxidative signaling pathway and activity of antioxidases to decrease produce of ROS,and by blocking these signaling pathways of PI3K/Akt,ERK/MAPK and TLR/MAPK to inhibit the expression of inflammatory cytokines,and activation of microgliocyte and astrocyte,and to produce neuroprotective effect in brain.Magnolol and honokiol improve function of 5-hydroxytryptaminergic nerve,and expression of brain-derived neurotrophic factor,and neurogenesis of hippocampus,to produce antidepressant-like effects.Magnolol and honokiol ameliorate depressant-like behaviors by down-regulating function of hypothalamus-hypophysis-adrenal axis.
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