Pharmacological effects and mechanisms of licorice extracts and active ingredients in metabolic associated fatty liver disease
Licorice,as the most commonly used medicinal plant,is widely used in the food and pharmaceutical industries.Licorice contains primarily triterpene saponins,flavonoids,and polysaccharide,which have various pharmacological effects such as antioxidant,immune regulation,antiviral,anti-inflammatory and liver protection.Modem research has found that licorice extracts and active ingredients,such as glycyrrhizic acid,glycyrrhetinic acid,licochalcone A,licorice total flavonoids and licorice extracts,can achieve the purpose of improving and treating metabolic associated fatty liver disease(MAFLD)by regulating glucose and lipid metabolism,reducing oxidative stress,altering gut microbiota,protecting intestinal barrier.This review mainly summarizes the research progress on the pharmacological effects and mechanisms of licorice extracts and active ingredients in treating MAFLD in recent years,aiming to provide theoretical basis for the clinical rational application and new drug development of this type of medication.
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