摘要
甘草是最常用的药用植物,广泛应用于食品及制药行业.甘草的化学成分主要有三萜皂苷类、黄酮类和多糖类等,具有抗氧化、免疫调节、抗病毒及抗炎保肝等多种药理作用.现代研究发现甘草提取物及有效成分(甘草酸、甘草次酸、甘草查尔酮A、甘草总黄酮等)能通过调节糖脂代谢、减轻氧化应激、改变肠道菌群、保护肠道屏障等机制达到改善及治疗代谢相关脂肪性肝病(MAFLD)的目的.综述近年来甘草提取物及有效成分抗MAFLD的药理作用及机制研究进展,旨在为该类药物的临床合理应用及新药研发提供理论依据.
Abstract
Licorice,as the most commonly used medicinal plant,is widely used in the food and pharmaceutical industries.Licorice contains primarily triterpene saponins,flavonoids,and polysaccharide,which have various pharmacological effects such as antioxidant,immune regulation,antiviral,anti-inflammatory and liver protection.Modem research has found that licorice extracts and active ingredients,such as glycyrrhizic acid,glycyrrhetinic acid,licochalcone A,licorice total flavonoids and licorice extracts,can achieve the purpose of improving and treating metabolic associated fatty liver disease(MAFLD)by regulating glucose and lipid metabolism,reducing oxidative stress,altering gut microbiota,protecting intestinal barrier.This review mainly summarizes the research progress on the pharmacological effects and mechanisms of licorice extracts and active ingredients in treating MAFLD in recent years,aiming to provide theoretical basis for the clinical rational application and new drug development of this type of medication.
基金项目
天津市卫生健康科技项目(TJWJ2022MS039)
NETL
NSTL
万方数据