Progress in pharmacology and clinical study of Chaihu Longgu Muli Decoction in treatment of perimenopausal syndrome
Chaihu Longgu Muli Decoction is a classic prescription contained in Discussion of Cold Damage.It can regulate the function of pivot,activate yang and dissipate heat,tranquilize and allay excitement,which is just in line with the key pathogenesis of dysfunction of pivot of perimenopausal syndrome(PMS).It is clinically used to treat PMS with outstanding efficacy,and its mechanism of action mainly involves the regulation of the neuroendocrine system;mitogen-activated protein kinase kinase(MEK)/extracellular signal-regulated kinase(ERK),estrogen receptor β(ERβ)/brain-derived neurotrophic factor(BDNF)/tyrosine protein kinase receptor B(TrkB)/serotonin 2A receptor(5-HT2A),estrogen receptor α(ERα)/phosphatidylinositol 3-kinase(PI3K)/serine threonine protein kinase(AKT)/y-aminobutyric acid(GABA)and other related signaling pathways regulation;O-linked β-N-acetylglucosamine(O-GlcNAc)modification of ERα.Clinical research has made some progress in regulating sleep and mood,improving neuroendocrine and reducing inflammatory response.This article collates and analyzes the pharmacological and clinical studies of Chaihu Longgu Muli Decoction in the treatment of perimenopausal syndrome,in order to provide reference for the clinical application and basic research of Chaihu plusLonggu Muli Decoction.
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