Clinical comprehensive evaluation of Huang'e Capsules
Objective To evaluate the clinical effectiveness of Huang'e Capsules,aiming to clarify its clinical advantages and promote rational drug use.Methods Based on literature and questionnaire research,comprehensive evidence and related data on shexiang tongxin were collected in the dimensions of safety,effectiveness,economy,innovation,suitability and accessibility.And multi-criteria decision analysis(MCDA)was used to comprehensively evaluate the clinical value of Huang'e Capsules.Results Based on the eight clinical guidelines,expert consensus or monographs publishd in the past five years,Huang'e Capsules are recommended for patients with qi deficiency,blood stasis and damp heat blockade.Alone,or combination with other positive drugs,Huang'e Capsules can effectively improve the total clinical response rate,maximum urine flow rate,reduce I-PSS score,reduce the frequency of nocturia,and rate the effectiveness as A.Adverse reactions are mostly general adverse reactions and the incidence of adverse reactions was 0-12.7％.No serious adverse reactions have been reported,the risk is known to be small,and the safety is rated A.Compared with placebo,increase 1％effective rate would extra cost 33.04 yuan for Huang'e capsule,economic rating of grade A.It has good clinical innovation and service innovation,and innovation is rated as A.There are no special storage conditions,medicinal material ingredients and other restrictions,and the clinical use meets the specifications of the medication guidelines,and the suitability is rated as A;Compared with proprietary Chinese medicines with Western medical indications,the price of Huang'e Capsules are relatively highwith the daily cost of 39.3 yuan,and the accessibility is rated as B.Conclusion A comprehensive evaluation of Huang'e Capsules was conducted using two methods,quantitative and qualitative,with evidence-based medicine as the main method.Research methods such as survey questionnaires,official website data,user experience,and pharmacoeconomic evaluation were combined to evaluate the accessibility of Huange Capsules.The accessibility was rated as B level,while the effectiveness,safety,economy,innovation,and suitability were all rated as A.
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