Clinical study of Xiao'er Chiqiao Qingre Granule combined with cefotaxime sodium in treatment of children with bacterial pneumonia
Objective To explore the curative effect of Xiao'er Chiqiao Qingre Granule combined with cefotaxime sodium and its influences on inflammatory factors in children with bacterial pneumonia.Methods A total of 108 children with bacterial pneumonia admitted to Liaocheng Second People's Hospital were enrolled between January 2020 and January 2023.According to random grouping method,they were divided into experimental group and control group,54 cases in each group.Patients in the control group were treated with cefotaxime sodium,while patients in experimental group were additionally treated with Xiao'er Chiqiao Qingre Granules.After seven days of treatment,clinical curative effect,scores of TCM syndromes and adverse reactions in the two groups were evaluated.The changes in levels of immune indexes and inflammatory factors before and after treatment were compared between the two groups.Results After 7 d of treatment,clinical curative effect of experimental group was significantly better than that of control group(P＜0.05).Before treatment,there was no significant difference in scores of TCM syndromes,immune indexes and inflammatory factors between the two groups(P＞0.05).After treatment,scores of TCM syndromes,levels of interleukin(IL)-6 and C-reactive protein(CRP)were significantly decreased(P＜0.05),while levels of immunoglobulin(Ig)A,IgG and IgM were significantly increased in both groups(P＜0.05).After treatment,scores of TCM syndromes,levels of IL-6 and CRP in experimental group were significantly lower than those in control group(P＜0.05),while levels of IgA,IgG and IgM were significantly higher than those in control group(P＜0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion Curative effect of Xiao'er Chiqiao Qingre Granule combined with cefotaxime sodium is good in children with bacterial pneumonia,which can significantly improve TCM syndromes,immune function and inflammatory response.
NETL
NSTL
万方数据
