Clinical observation of Luofushan Fengshi Gao combined with glucosamine sulfate in treating knee osteoarthritis of wind cold and damp bi type
Objective To explore the clinical efficacy of Luofushan Fengshi Gao combined with glucosamine sulfate in the treatment of knee osteoarthritis with wind cold dampness type.Method A total of 122 patients with knee osteoarthritis(wind cold dampness bi type)admitted to Guang'anmen Hospital,Chinese Academy of Traditional Chinese Medicine from September 2021 to May 2022 were selected.They were randomly divided into a control group and an experimental group,with 61 cases in each group.The control group was treated with glucosamine sulfate,while the experimental group was treated with Luofushan Fengshi Gao.The clinical efficacy of the two groups was compared,and the TCM syndrome scores before and after treatment were compared between the two groups,severity of the condition[McMaster University(WOMAC)],knee function[Lysholm Knee Score(LKSS)],quality of life[Activity of Daily Living(ADL)],bone metabolism indicators[BGP,OPG,CTX-Ⅰ,CTX-Ⅱ],pain related mediators[serum substance P(SP),prostaglandin E2(PGE2),serotonin(5-HT)],Inflammatory cytokine levels[interleukin-1β(IL-1β),interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α),C-reactive protein(CRP)]and the incidence of adverse reactions were calculated.Results The total effective rate of the two groups was higher in the experimental group(P＜0.05).There was no statistically significant difference in the scores of traditional Chinese medicine syndromes,severity of the condition,bone metabolism indicators,pain related mediators,and levels of inflammatory factors between the two groups before treatment(P＞0.05).After treatment,the TCM syndrome scores of both groups of patients were significantly reduced compared to before treatment(P＜0.05),and the experimental group was significantly lower than the control group after treatment(P＜0.05).After treatment,the WOMAC scores of both groups were significantly reduced compared to before treatment in same group(P＜0.05),while the LKSS and ADL scores of both groups were significantly increased compared to before treatment in same group(P＜0.05).Moreover,the WOMAC scores of the experimental group were lower than those of the control group,while the LKSS and ADL scores were higher than those of the control group(P＜0.05).There was no statistically significant difference in bone metabolism indicators between the two groups(P＞0.05),pain related mediators SP,PGE2,and 5-HT in both groups were significantly reduced compared to before treatment in same group(P＜0.05),and the levels of SP,PGE2,and 5-HT in the experimental group were significantly lower than those in the control group(P＜0.05).Two groups of inflammatory cytokine IL-1 β,IL-6,TNF-α,CRP levels were significantly reduced compared to before treatment in same group(P＜0.05),and IL-1β,IL-6,TNF-α,and CRP levels in the experimental group were also significantly reduced than those of the control group(P＜0.05).The time for pain relief,pain disappearance,and joint range of motion normalization in the experimental group were all shorter than those in the control group(P＜0.05).The incidence of adverse reactions in both groups was not statistically significant(P＞0.05).Conclusion The combination of Luofushan Fengshi Gao and glucosamine sulfate has a significant effect on the treatment of patients with wind cold dampness type knee osteoarthritis.It can alleviate the condition,improve knee joint function,improve quality of life,reduce pain mediators,alleviate inflammatory reactions,and has high safety.
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