Correlation between vasoactive drugs and acute renal injury after aortic dissection surgery
Objective To investigate the risk factors of acute kidney injury(AKI)after aortic dissection surgery and analyze the cor-relation between AKI and vasoactive drugs.Methods The clinical data of 334 patients with acute type A aortic dissection admitted to Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology from October 2020 to March 2022 were selected,and 272 patients met the inclusion criteria.According to whether AKI occurred after surgery,the patients were divided into AKI group(n=223)and non-AKI group(n=49),and the influencing factors of postoperative AKI were analyzed by multivari-ate Logistic regression analysis.At the same time,according to the different vasoactive drugs given,the patients were divided into single drug group(dopamine alone,n=98)and multi-drug group(dopamine and epinephrine and/or norepinephrine and/or dobuta-mine in two or three combinations,n=174),and the incidence of postoperative AKI was compared between the two groups.Results Age,cardiopulmonary bypass time,postoperative TnI level,and BMI in the AKI group were higher than those in the non-AKI group(P＜0.05).Age,obesity,more than two kinds of vasoactive drugs,and postoperative TnI were independent risk factors for AKI after aortic dissection surgery(P＜0.05).The incidence of postoperative AKI in the single drug group was lower than that in the multi-drug group(P＜0.05).Conclusion Age,obesity,more than two kinds of vasoactive drugs,postoperative TnI are independent risk factors for AKI after aortic dissection surgery.When using more than two kinds of vasoactive drugs,the prevention and treatment of postoperative AKI should be strengthened.
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