Study on medication pattern and its mechanism of action of heat-clearing and detoxification formula for psoriasis based on data mining
Objective To explore the rules of medication for psoriasis using heat-clearing and detoxifying prescriptions,and predicted the commonly used drug combinations for the treatment of psoriasis.For the most commonly used drug combinations,the syndrome types and clinical dosages commonly used in the treatment of psoriasis alone and in combination were analyzed,in order to provide a basis for clinical use.Methods The relevant documents of the use of heat-clearing and detoxifying prescriptions in CNKI,VIP,Wanfang data and PubMed databases were retrieved,and frequency,clustering and associated analysis of the Chinese medicine used in the document prescription were analyzed.Based on related rules,core drugs with higher confidence and high support were chosed,and core drugs-active ingredients-intersection target network diagram were established,and a series of analysis,including the enrichment of genetic entity functions and Kyoto Analysis of genes and genome encyclopedia were conducted.Results After screening,162 articles were included,including 129 prescriptions,involving 159 Chinese medicine flavors,and a total frequency of 1 448 times.High-frequency Chinese materia medica such as Rehmanniae Radix,Smilacis Glabrae Rhizoma,Paeoniae Radix Rubra,Moutan Cortex,Glycyrrhizae Radix et Rhizoma were 21 flavors,among which heat-clearing drugs and bitter-cold drugs were in the majority,mostly classified into the liver meridian.The associated analysis has been paired with the most supportive and confident drugs to be"Rehmanniae Radix-Paeoniae Radix Rubra".Classification analysis obtained three clustering class.Network pharmacology yielded 17 potential active components of Rehmanniae Radix with 79 anti-psoriasis targets,15 potential active components of Paeoniae Radix Rubra with 91 anti-psoriasis targets,and 114"Rehmanniae Radix-Paeoniae Radix Rubra"anti-psoriasis targets.Interestingly,among the potential active ingredients of the drugs,Rehmanniae Radix and Paeoniae Radix Rubra had only one common component,but the signaling pathways enriched by"Rehmanniae Radix-Paeoniae Radix Rubra"including multiple classical signaling pathways,mainly involving in cancer-related pathways,lipids and atherosclerotic pathways,phospholipidsitol-3-hydroxykinase-protein kinase B signaling pathway,hypoxia-induciblefactor-1 signaling pathway,mitogen activated protein kinases signal pathway,TH 17 cell differentiation pathway.Conclusion The core drug combination in the treatment of psoriasis by clearing heat and removing toxins is Rehmanniae Radix and Paeoniae Radix Rubra.Rehmanniae Radix or Paeoniae Radix Rubra alone treated single syndrome psoriasis through multiple signaling pathways.two combined played a therapeutic role in the treatment of different or multiple syndromes psoriasis by interfering with multiple targets through multiple components,and then modulate multiple psoriasis-related signaling pathways.
psoriasisheat-clearing and detoxificationdata miningnetwork pharmacologycompatibility rulesRehmanniae RadixPaeoniae Radix Rubra
NETL
NSTL
万方数据
