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功能性消化不良动物模型的中医证型及其评价指标研究进展

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功能性消化不良(FD)作为功能性胃肠病,中医临床通过病症结合的方式进行治疗,将其分为脾虚气滞证、肝胃不和证、脾胃湿热证、脾胃虚寒证、寒热错杂证、肝郁脾虚证、肝郁气滞证等证型.FD动物模型的构建依据证型特定的发病机制来模拟人体症状,检测指标常采用行为学、胃肠动力学及相关蛋白水平等评估模型与FD患者的相似度.符合病症的动物模型是开展药效研究和药效评价的前提和基础,对FD中医证型的造模方法及检测指标进行整理和分析,旨在完善和优化动物模型,为后续的药物研究提供支持.
Research progress on animal models of functional dyspepsia in traditional Chinese medicine syndromes and evaluation indicators
Functional dyspepsia(FD),as a functional gastrointestinal disease,is treated in traditional Chinese medicine through a combination of symptoms and symptoms.FD is divided into spleen deficiency and qi stagnation syndrome,liver stomach disharmony syndrome,spleen stomach damp heat syndrome,spleen stomach deficiency and cold syndrome,mixed cold and heat syndrome,liver depression and spleen deficiency syndrome,and liver depression and qi stagnation syndrome.The construction of FD animal models is based on the specific pathogenesis of syndrome types to simulate human FD symptoms,and detection indicators often use behavioral,gastrointestinal dynamics,and related protein levels to evaluate the similarity between the model and FD patients.Animal models that meet the symptoms are the prerequisite and foundation for conducting pharmacological research and evaluation.The modeling methods and detection indicators of traditional Chinese medicine syndrome types in FD are currently organized and analyzed,aiming to improve and optimize the FD animal model and provide support for subsequent drug research.

functional dyspepsiaanimal modelstraditional Chinese medicine syndrome typescombination of disease and syndromeevaluating indicator

马玉朋、袁亚茹、邸志权、姜溪、胡金芳

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天津中医药大学,天津 301617

天津天诚新药评价有限公司,天津 300462

药物成药性评价与系统转化全国重点实验室,天津 300462

天津市药代动力学和药效动力学重点实验室,天津 300462

天津市新药非临床评价技术工程中心,天津 300462

安徽医科大学,安徽合肥 230032

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功能性消化不良 动物模型 中医证型 病证结合 评价指标

"重大新药创制"科技重大专项天津市科技计划天津市科技计划

2015ZX0950100416PTGCCX0009017ZXXYSY00020

2024

药物评价研究
天津药物研究院 中国药学会

药物评价研究

CSTPCD北大核心
影响因子:1.199
ISSN:1674-6376
年,卷(期):2024.47(4)
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