功能性消化不良动物模型的中医证型及其评价指标研究进展
Research progress on animal models of functional dyspepsia in traditional Chinese medicine syndromes and evaluation indicators
马玉朋 1袁亚茹 2邸志权 3姜溪 3胡金芳3
作者信息
- 1. 天津中医药大学,天津 301617;天津天诚新药评价有限公司,天津 300462;药物成药性评价与系统转化全国重点实验室,天津 300462;天津市药代动力学和药效动力学重点实验室,天津 300462;天津市新药非临床评价技术工程中心,天津 300462
- 2. 天津天诚新药评价有限公司,天津 300462;安徽医科大学,安徽合肥 230032;药物成药性评价与系统转化全国重点实验室,天津 300462;天津市药代动力学和药效动力学重点实验室,天津 300462;天津市新药非临床评价技术工程中心,天津 300462
- 3. 天津天诚新药评价有限公司,天津 300462;药物成药性评价与系统转化全国重点实验室,天津 300462;天津市药代动力学和药效动力学重点实验室,天津 300462;天津市新药非临床评价技术工程中心,天津 300462
- 折叠
摘要
功能性消化不良(FD)作为功能性胃肠病,中医临床通过病症结合的方式进行治疗,将其分为脾虚气滞证、肝胃不和证、脾胃湿热证、脾胃虚寒证、寒热错杂证、肝郁脾虚证、肝郁气滞证等证型.FD动物模型的构建依据证型特定的发病机制来模拟人体症状,检测指标常采用行为学、胃肠动力学及相关蛋白水平等评估模型与FD患者的相似度.符合病症的动物模型是开展药效研究和药效评价的前提和基础,对FD中医证型的造模方法及检测指标进行整理和分析,旨在完善和优化动物模型,为后续的药物研究提供支持.
Abstract
Functional dyspepsia(FD),as a functional gastrointestinal disease,is treated in traditional Chinese medicine through a combination of symptoms and symptoms.FD is divided into spleen deficiency and qi stagnation syndrome,liver stomach disharmony syndrome,spleen stomach damp heat syndrome,spleen stomach deficiency and cold syndrome,mixed cold and heat syndrome,liver depression and spleen deficiency syndrome,and liver depression and qi stagnation syndrome.The construction of FD animal models is based on the specific pathogenesis of syndrome types to simulate human FD symptoms,and detection indicators often use behavioral,gastrointestinal dynamics,and related protein levels to evaluate the similarity between the model and FD patients.Animal models that meet the symptoms are the prerequisite and foundation for conducting pharmacological research and evaluation.The modeling methods and detection indicators of traditional Chinese medicine syndrome types in FD are currently organized and analyzed,aiming to improve and optimize the FD animal model and provide support for subsequent drug research.
关键词
功能性消化不良/动物模型/中医证型/病证结合/评价指标Key words
functional dyspepsia/animal models/traditional Chinese medicine syndrome types/combination of disease and syndrome/evaluating indicator引用本文复制引用
基金项目
"重大新药创制"科技重大专项(2015ZX09501004)
天津市科技计划(16PTGCCX00090)
天津市科技计划(17ZXXYSY00020)
出版年
2024
NETL
NSTL
万方数据