Research progress on chemical constituents and anti-tumor effects of Fomitopsis officinalis
Agarikon is the dried fruiting body of Fomitopsis officinalis,which has the functions of inhibiting bacteria and reducing inflammation,relieving cough and asthma,dispelling wind and removing dampness,relieving swelling and pain,and anticancer.The chemical components(including triterpenic acid,steroids,sesquiterpenoids and polysaccharides)and their inhibitory effects on liver cancer,breast cancer,lung cancer and gastric cancer were summarized.This paper provides some useful ideas and directions for the further research and development of Fomitopsis officinalis.The extraction sites and active components of Fomitopsis officinalis have the characteristics of multi-components and multi-targets for anti-tumor.The mechanism of action includes inhibition of tumor cell proliferation,induction of apoptosis,inhibition of tumor cell migration and invasion,enhancement of immunity and inhibition of tumor angiogenesis.
AgarikonFomitopsis officinalis(Vill.ex Fr.)Bond.et Sing.antitumorliver cancerbreast cancerlung cancergastric cancer
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