Research progress on pharmacological effects of extracts and effective parts of Rubus parvifolius
Rubus parvifolius is a small deciduous shrub of the genus Rubus in the family Rosaceae,and studies have shown that its extracts and effective parts have pharmacological effects such as anti-tumor,neuroprotective,antioxidant and hepatoprotective.Anti-tumor is its research focus,in vitro and in vivo experiments,extracts of R.parvifolius.have shown significant anti-tumor effects on human malignant melanoma,leukemia and liver cancer,significantly inhibiting the growth,invasion and migration of tumor cells and inducing apoptosis,the main anti-tumor effective part is total saponins of R.parvifolius.Extracts of Rubus parvifolius also have neuroprotective effects in cerebral ischemia-reperfusion injury,the mechanism of action is to increase Bcl-2 expression and decrease Bax expression,the main effective part is total saponins of R.parvifolius.The antioxidant capacity of R.parvifolius extracts is related to the scavenging of hydroxyl radicals,superoxide negative ions,organic free radicals and the inhibition of malondialdehyde,etc.And the main effective part is the total flavonoids of R.parvifolius.Extracts of R.parvifolius also have a protective effect against liver damage,associated with free radical scavenging activity,with phenolic compounds as the main effective part.Other pharmacological effects of the extracts and effective parts of R.parvifolius include anti-inflammatory,anti-bone resorption,antibacterial,anti-fatigue,etc.This article reviewed the pharmacological effects and research status of the extracts and active components of R.parvifolius,to provide a reference for further research and development of new drugs in R.parvifolius.
Rubusparvifolius L.saponintotal saponins of Rubusparvifolius.flavonoidsantitumourneuroprotectionmelanoma
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