Research progress on liver injury caused by anti-thyroid drugs
Pharmacotherapy is the main treatment for hyperthyroidism.The commonly used antithyroid agent include propylthiouracil,methimazole and its precursor,carbimazol.These antithyroid agent can cause varying degrees of liver damage.Although antithyroid agent hepatotoxicity has been recognized for more than 70 years,there are still some new reports and explanations in recent years.This article reviews and analyzes the research progress in the incidence,clinicopathological features,mechanism and prevention of liver injury caused by common antithyroid agent,to provide reference for clinical safety and rational drug use.
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