Research progress on evaluation of hepatotoxicity of traditional Chinese medicine based on zebrafish model
The extensive use of Chinese medicine increases the risk of liver toxicity.While zebrafish model shows great potential in hepatotoxicity research,it also faces the problem that evaluation criteria are difficult to unify.Before using zebrafish for drug liver injury detection,the liver function status of zebrafish at different growth stages should be clearly defined.Given that the whole transparent characteristics of zebrafish embryos and juvenile fish,the preliminary developmental toxicity judgment can be made based on the hatching rate,mortality rate and deformity rate of embryos.The degree of yolk sac absorption is used as the criterion to judge whether the drug has hepatotoxicity.The mechanism of hepatotoxicity is studied by using the characteristics of easy separation of adult fish liver.These indicators can be used to determine the liver development stage of zebrafish and provide evidence for whether drug liver injury occurs,so as to further improve clinical drug safety.This paper reviewed the research methods and progress of evaluating hepatotoxicity of traditional Chinese medicine in zebrafish at different developmental stages,in order to provide reference for the subsequent detection of hepatotoxicity of traditional Chinese medicine.
traditional Chinese medicinezebrafishliver injuryhepatotoxicitydrug-induced liver injurydetection of hepatotoxicity
NETL
NSTL
万方数据
