Research progress on drug-induced liver injury induced by statins
Statins are a kind of comprehensive lipid-regulating drugs,which can effectively reduce serum total cholesterol(TC)and low density lipoprotein(LDL).Statins are widely used in the prevention and treatment of cardiovascular disease.In recent years,with the wide application of statins,the research on their adverse reactions is becoming increasingly in-depth.Hepatotoxicity is one of the important adverse reactions caused by such drugs.Drug-induced liver injury(DILI)occasionally occurs during the use of statins.This paper summarizes the research progress on the influencing factors,related mechanisms,and prevention and treatment strategies of DILI caused by statins,aiming to provide a basis for rational clinical use of statins and prevention of DILI.
statinslipid-regulating effectadverse reactionsdrug-induced liver injuryrational drug use
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