Literature analysis of adverse drug reactions caused by brivaracetam in children
Objective To analyze the general rules and characteristics of adverse drug reactions caused by brivaracetam in children,and to provide reference for clinical safety of drug use.Methods Clinical trial studies and case reports of adverse drug reactions caused by brivaracetam in children were searched from PubMed,CNKI,WanFang Data and VIP.The time limit for the search was from the establishment of the databases to January 31,2024.The gender,age,usage and dosage of brivaracetam,combined drug use and ADR clinical manifestations of patients were statistically analyzed.Results A total of 13 literatures were included,with a total of 849 patients,including 458 males(53.9％)and 391 females(46.1％).ADR involved 6 systems/organs,which were mainly nervous system(39.22％)and mental diseases(31.86％),such as somnolence,seizure worsening,convulsion,irritability,aggression,psychomotor hyperactivity,behavioral problems.The most of ADR are reversible and have a good prognosis,but some patients still have adverse outcomes or even death after active treatment.Conclusions Brivaracetam can cause serious ADR in children.Clinical attention should be paid to the rational use of brivaracetam,and the monitoring and follow-up should be strengthened to ensure the safety ofpatients.
brivaracetamchildrenepilepsyadverse drug reactionsnervous systemmental diseases
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