Therapeutic effect of terbutaline sulfate combined with ambroxol hydrochloride in elderly AECOPD patients
Objective To explore the therapeutic effects of terbutaline sulfate and ambroxol hydrochloride on elderly patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods Ninety AECOPD patients admitted to the Affiliated Hospital of Shandong University of Chinese Medicine were divided into the control group and the experimental group with equal number of cases(n=45)according to ttreatment regimen,and both groups were treated according to the basic treatment plan in the diagnosis and treatment guideline,in which the control group was treated with Ambroxol Hydrochloride Injection,and the experimental group was treated with Terbutaline Sulfate Inhalation Powder Aerosol added to the treatment plan of the control group,and both groups were treated for 7 d.The recovery time of clinical symptoms was compared between the two groups,and all the lung function indexes,serum inflammatory factor,airway remodeling indexes before and after treatment were compared,and the adverse reactions occurred during the treatment were recorded.Results The total effective rate of treatment in the experimental group was 95.56％,which was significantly higher than that of the control group(80.00％).The time for the disappearance of high fever,chest tightness,cough,sputum,and pulmonary wet rales in the experimental group was shorter than that in the control group(P＜0.05).Before treatment,there was no statistically significant difference in chronic obstructive pulmonary disease assessment test scale(CAT)scores between the two groups(P＞0.05).After treatment,CAT scores of both groups were significantly lower than those before treatment in same group(P＜0.05),and the experimental group was significantly lower than the control group(P＜0.05).Before treatment,there was no statistically significant difference in various lung function indexes between the two groups(P＞0.05).After treatment,the first second expiratory volume of exertion accounted for the predicted value(FEV1),peak expiratory flow rate accounted for the predicted value(PEF),FEV1/exertion lung volume(FVC),and maximal expiratory flow rate at 25％ of lung volume(25％MEF)of the two groups were all significantly improved compared with that of the group before treatment(P＜0.05)and the improvement effect was more obvious in the experimental group than in the control group(P＜0.05).Before treatment,there was no statistically significant difference in serum inflammatory factor levels between the two groups(P＞0.05).After treatment,the levels of interleukin(IL)-6,IL-8,eosinophils(EOS),and airway remodeling indexes,serum matrix metalloproteinase(MMP)-9,transforming growth factor β1(TGF-β1),and basic fibroblast growth factor(bFGF)were significantly lower in the experimental group than in the control group(P＜0.05).Before treatment in this group were significantly lower(P＜0.05),and the indicators in the experimental group were lower than those in the control group(P＜0.05).There was no significant difference in the adverse reactions between the two groups during treatment(P＞0.05).Conclusion Terbutaline sulfate combined with ambroxol hydrochloride achieved better results in the treatment of AECOPD in the elderly,which can improve the patients'lung function,reduce the expression of serum inflammation,and improve their airway remodeling,and is worthy of clinical application.
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