注射用益气复脉(冻干)对冠心病射血分数保留的心力衰竭患者N末端B型脑钠肽前体、无创心功能指标及生活质量的影响

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中文摘要：目的观察注射用益气复脉(冻干)对冠心病射血分数保留的心力衰竭(HFpEF)患者的N末端B型脑钠肽前体(NT-proBNP)、无创心功能相关指标、明尼苏达心力衰竭生活质量评分(MLHFQ)的影响.方法选择128例2021年12月-2023年2月在中南大学湘雅二医院心内科住院的HFpEF患者为研究对象,随机分为对照组及试验组,最终纳入对照组60例、试验组61例.对照组予常规抗心衰治疗,试验组在常规治疗的基础上加用注射用益气复脉(冻干),每次5.2 g,用250 mL 5％葡萄糖注射液或0.9％氯化钠注射液稀释后静脉滴注,每日1次,两组均连续治疗7d.观察两组治疗前后NT-proBNP、无创心功能相关指标、MLHFQ水平变化及安全性.结果干预7 d后,试验组NT-proBNP水平、无创心功能指标中的射血前期(PEP)、MLHFQ评分均低于对照组,差异均具有统计学意义(P＜0.05).两组不良反应发生情况无显著差异(P＜0.05).结论注射用益气复脉(冻干)可改善HFpEF患者的NT-proBNP、无创心功能指标PEP和MLHFQ评分,且未见明显临床不良反应,可用于治疗冠心病HFpEF患者.

外文标题：Effects of Yiqi Fumai Lyophilized Injection on NT-proBNP,noninvasive cardiac function indices,and quality of life in heart failure patients with preserved ejection fraction in coronary artery disease

外文摘要：Objective To observe the effect of Yiqi Fumai Lyophilized Injection on NT-proBNP,noninvasive cardiac function indices,and quality of life in patients with coronary heart disease HFpEF.Methods 128 patients with coronary heart disease HFpEF were selected as the study objects and randomly divided into experimental group and control group,61 cases in experimental group and 60 cases in control group,finally.Patients in the control group were given conventional anti-heart failure treatment,and patients in the experimental group were given Yiqi Fumai Lyophilized Injection on the basis of the above treatment,5.2 g each time,diluted with 250 ml 5％Glucose Injection or 0.9％Sodium Chloride Injection once a day,and both groups were used continuously for 7 seven days.N-terminal B-type brain natriuretic peptide precursor(NT-proBNP),noninvasive cardiac function related indicators,Minnesota Heart Failure Quality of Life Score(MLHFQ)level changes were observed in the two groups before and after treatment.Results After seven days of intervention,the level of NT-proBNP,non-invasive cardiac function index PEP and MLHFQ score in experimental group were lower than those in control group,with statistical significance(P＜0.05).Conclusion Yiqi Fumai Lyophilized Injection is effective in patients with CHD with ejection fraction retention heart failure,and no obvious clinical adverse reactions have been observed.It can be used as a new measure for the treatment of CHD HFpEF.

外文关键词：

Yiqi Fumai Lyophilized Injectionejection fraction retention heart failurecoronary heart diseaseN-terminal B-type brain natriuretic peptide precursor (NT-proBNP)noninvasive cardiac function related indicatorsMinnesota Heart Failure Quality of Life Scor

作者：

王琼、许丹焰

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作者单位：

云南省阜外心血管病医院心内科,云南昆明 650000

中南大学湘雅二医院心内科,湖南长沙 410000

关键词：

注射用益气复脉(冻干) 射血分数保留心力衰竭冠心病 N末端B型脑钠肽前体(NT-proBNP) 无创心功能相关指标明尼苏达心力衰竭生活质量评分

基金：

国家自然科学基金

项目编号：

82172550

出版年：

2024

DOI：

10.7501/j.issn.1674-6376.2024.05.020

药物评价研究

天津药物研究院中国药学会

药物评价研究

CSTPCD北大核心

影响因子：1.199

ISSN：1674-6376

年,卷(期)：2024.47(5)