Analysis and comparison of prescription rules of Licorice and Dried Ginger Decoction in ancient and modern times
Objective To analyze and compare the similarities and differences in the pattern of grouping and medication dispensing of Licorice and Dried Ginger Decoction in ancient Chinese medicine dictionaries and modem Chinese medicine clinical prescriptions.Methods From the Dictionary of Traditional Chinese Medicine Formulas and the inpatient prescriptions issued by doctors of First Affiliated Hospital of Henan University of Chinese Medicine from 2017 to 2019,respectively,all formulas containing licorice-dried ginger,prepared licorice-dried ginger,licorice-canned ginger,or prepared licorice-canned ginger pairs were screened,and the groupings were standardized uniformly,and software such as SPSS v18.0 and Cytoscape were applied.The extracted data were statistically and comparatively analyzed in terms of frequency of medication,dosage,proportion of compounding,and disease family.Results 2 743 and 24 354 formulas were screened from the Dictionary of Traditional Chinese Medicine Formulas and clinical prescriptions,respectively.Among them,formulas containing prepared licorice and dried ginger,which accounted for 59.8%and 48.0%of the total number of formulas respectively,appeared most frequently,and among the formulas obtained from the screening,the frequency of the 1∶1 ratio was the highest.In the Dictionary of Chinese Medicine Formulas,the disease families treated by licorice-dried ginger,prepared licorice-dried ginger were mainly spleen and stomach diseases,and the disease families treated by licorice-canned ginger and prepared licorice-canned ginger were mainly gynecological diseases;in the clinical prescriptions of modem Chinese medicine,the disease families treated by licorice-dried ginger,licorice-canned ginger and prepared licorice-dried ginger were mainly spleen,stomach,liver,and gallbladder diseases,and the disease families treated by prepared licorice-canned ginger were mainly obstetrics and gynaecology diseases.Conclusion The ancient and modem applications of Licorice and Dried Ginger Decoction are most commonly used in the ratio of 1∶1 of prepared licorice-dried ginger,and the diseases treated are mainly in the spleen and stomach,and this study can provide a basis for the modem clinical application of this medicinal pair and the development of scientific research.