Research progress on active mechanism of icariin in promoting repair of articular cartilage damage
Icariin is the main active monomer of the kidney tonic Chinese medicine Epimedii Folium,belonging to isopentenylflavonol compounds,with multiple pharmacological activities such as immunomodulation,anti-inflammation,anti-oxidative stress,anti-tumor and aging,anti-osteoporosis and other multiple pharmacological activities,which is effective in neurological,immunological,oncological,endocrinological,cardio-cerebral,cerebral,vascular and musculoskeletal system disorders,especially in the skeletal system diseases,with a multichannel and multi-targeted active effect,in particular,it has multi-channel and multi-target active effects on skeletal system diseases,and has potential application advantages in articular cartilage damage diseases.Icariin can promote the repair of articular cartilage damage by promoting chondrocyte proliferation and differentiation,inhibiting excessive apoptosis,decreasing the release of inflammatory factors,inhibiting the remodeling of subchondral bone structure,promoting the synthesis of extracellular matrix in articular cartilage,and promoting the migration and chondrogenic differentiation of bone marrow mesenchymal stem cells,and many other mechanisms of action.Now,we review the different repairing effects played by icariin in the treatment of articular cartilage damage diseases and its mechanism,in order to provide reference basis for in-depth research and related drug development.
articular cartilage damageicariincartilage repairmechanism of actionchondrogenic differentiation
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