Research progress on pharmacological mechanism of monomer components from traditional Chinese medicine targeting pathways related to cerebral ischemic stroke
Cerebral ischemic stroke(CIS)seriously affects the quality of life of patients due to its high disability rate,high mortality rate and high recurrence rate.Studies have found that traditional Chinese medicine monomer components can prevent and treat CIS through a variety of signaling pathways,such as curcumin,artesunate,baicalin,salvianolic acid D,saikosaponin A,berberine,palmatine,isorhynchophylline,triptolide,astragaloside IV,salidroside,ginsenoside Rg1,dandelionol,peony glycoside and other traditional Chinese medicine monomers can regulate signaling pathway such as nuclear factor κB(NF-κB),high mobility group protein B1(HMGB1),adenosine monophosphate-activated protein kinase(AMPK),mammalian target of rapamycin(mTOR),phosphatidylinositol 3-kinase/protein kinase B(PI3K/Akt),and nuclear transcription factor red lineage 2-related factor 2(Nrf2).The mechanisms related to the effects of monomers from traditional Chinese medicine on the above six signaling pathways were reviewed,in order to provide new ideas and directions for the in-depth study of the prevention and treatment of CIS,and to provide a theoretical basis and reference for the clinical application of traditional Chinese medicine in prevention and treatment of CIS.
monomer components from traditional Chinese medicinecerebral ischemic strokesignaling pathwaycurcuminsaikosaponin Aberberineastragaloside Ⅳginsenoside Rg1
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