Research progress on pharmacological effects and mechanism of Pulsatilla chinensis
Pulsatillae Radix,the dried root of Pulsatilla chinensis,a plant belonging to the Ranunculaceae family,is a commonly used traditional Chinese medicine.It was first recorded in the"Shen Nong Ben Cao Jing".It has a slight odor and a slightly bitter taste,with the efficacy of clearing heat and detoxification.Pulsatillae Radix extract and its active components have shown significant anti-tumor effects on various types of cancer including lung cancer,colorectal cancer,liver cancer,gastric cancer,ovarian cancer,leukemia,melanoma,etc.It can significantly inhibit the growth and metastasis of tumor cells,with the main active component in its anti-tumor effect being Pulsatilla Radix saponin.Pulsatilla Radix saponins and extracts also have protective effects on cardiovascular diseases such as atherosclerosis,myocarditis,hypertension,respiratory diseases such as chronic obstructive pulmonary disease and asthma,autoimmune diseases such as psoriasis,systemic lupus erythematosus,rheumatoid arthritis,neurodegenerative diseases such as Alzheimer's disease,Parkinson's disease,etc.Other effects of Pulsatilla Radix extracts and active components include anti-aging,antibacterial,antiviral,and hypoglycemic effects.This review summarizes the pharmacological effects and research status of Pulsatillae Radix extracts and active components,aiming to provide a theoretical basis for further research and new drug development of Pulsatillae Radix.
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