Analysis of factors influencing plasma trough concentration of sertraline hydrochloride in children with depression
Objective To evaluate the distribution characteristics and influencing factors of sertraline trough concentration in patients with depression in Xinjiang.Methods Liquid chromatography-mass spectrometry(LC-MS)was used to determine the plasma trough concentrations of 119 patients with depression who took sertraline from January 2022 to November 2023,and the distribution characteristics and influencing factors of sertraline trough concentrations were analyzed.Results Among the 119 children,the plasma trough concentration of sertraline＜10 ng·mL-1,and the trough concentration of sertraline in 105 children was within the therapeutic concentration range(10-150 ng·mL-1).The dose of sertraline administered was positively correlated with the plasma trough concentration,but the correlation was poor(r=0.223,P＜0.05).The concentration to dose ratio(CDR)value of sertraline in male children was significantly higher than that of female children(t ＝-2.399,P＜0.05),the CDR value of sertraline in Han children was significantly higher than that of Uygur children(t=2.505,P＜0.05),and the CDR value of sertraline in children with body mass index(BMI)＞24.0 kg·m-2 was significantly higher than that of children with BMI＜18.5 kg·m-2 and 18.5 kg·m-2≤BMI ≤ 24.0 kg·m-2(F=15.345,P＜0.05).Conclusion The trough plasma concentration of sertraline varies widely among children with depression,and gender,ethnicity,and BMI may affect the trough plasma concentration of sertraline.
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