基于Nrf2/HO-1信号通路的中药有效成分缓解肝损伤研究进展
Research progress on alleviation of liver injury by active ingredients of traditional Chinese medicine based on Nrf 2/HO-1 signaling pathway
罗美美 1朱星宇 1胡乐涛 1吴育 2李伟东1
作者信息
- 1. 南京中医药大学江苏省中药炮制重点实验室、国家教育部中药炮制规范化及标准化工程研究中心,江苏南京 210023;南京中医药大学药学院,江苏南京 210023
- 2. 南京中医药大学江苏省中药炮制重点实验室、国家教育部中药炮制规范化及标准化工程研究中心,江苏南京 210023;南京中医药大学南通附属医院临床研究中心,江苏南通 226000
- 折叠
摘要
近年研究己证实,氧化应激是造成肝损伤的重要因素,研究发现核因子E2相关因子2(Nrf2)/血红素氧合酶-1(HO-1)可以通过调控氧化应激以缓解肝损伤.中药单体或中药复方可以通过调控该信号通路减少氧化应激、铁死亡、炎症和细胞焦亡的发生以缓解肝损伤.对中药中的黄酮类、多糖、酚酸、甾体类等有效成分通过Nrf2/HO-1信号通路在氧化应激与肝损伤之间的相互作用进行综述,对于寻求靶向Nrf2/HO-1信号通路发挥缓解肝损伤作用的中药提供依据,同时为中药治疗肝损伤作用机制的深入研究提供参考.
Abstract
Oxidative stress is an important factor in liver injury,and studies have found that nuclear factor E2-related factor 2(Nrf 2)/heme oxygenase-1(HO-1)can alleviate liver injury by regulating oxidative stress.Traditional Chinese medicine(TCM)monomers or TCM compounds can alleviate liver injury by regulating this signaling pathway to reduce the occurrence of oxidative stress,ferroptosis,inflammation and pyroptosis.This article integrates the active ingredients such as flavonoids,polysaccharides,phenolic acids,and sterols in TCM to review the interaction between oxidative stress and liver injury through this signaling pathway,which provides strong evidence for seeking TCM that targets the Nrf 2/HO-1 signaling pathway to play a role in alleviating liver injury,provides effective ideas for further exploring the multi-faceted drug effects of effective substances in TCM,and provides a reference for the development of pharmacodynamics and in-depth research on the mechanism of action of TCM.
关键词
中药/核因子E2相关因子2(Nrf2)/血红素氧合酶-1(HO-1)信号通路/氧化应激/肝损伤/黄酮类/多糖类/酚酸/甾体类Key words
traditional Chinese medicine/signal pathway of Nrf 2/HO-1/oxidative stress/liver damage/flavonoids/polysaccharides/phenolic acids/sterols引用本文复制引用
基金项目
国家自然科学基金面上项目(81973484)
国家自然科学基金青年项目(82304736)
南京中医药大学青年基金项目(XZR2021085)
出版年
2024
NETL
NSTL
万方数据