Research progress on preclinical evaluation models of CAR-T cell therapy products
The treatment of cancer has always been regarded as the biggest challenge in medicine.In recent years,with the approval and launch of various chimeric antigen receptor T cell therapy(CAR-T)products,new hope has been brought to the research of overcoming cancer.However,in clinical practice,CAR-T cell therapy products have certain adverse reactions,which suggests that preclinical evaluation models of CAR-T cell therapy products is crucial.At present,the preclinical evaluation methods for CAR-T cell therapy products mainly include in vivo evaluation models and in vitro evaluation models.In vivo evaluation models include syngeneic mouse model,genetically engineered mouse models,humanized mouse models,patient-derived tumor xenograft models and non-human primate models.In vitro evaluation models include patients derived organoids models,human-on-a-chip models and artificial intelligence prediction.This article aims to review the progress and advantages and disadvantages of various evaluation methods to lay a theoretical and research foundation for preclinical evaluation of CAR-T cell therapy products.
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