Effect of montmorillonite powder combined with probiotics on intestinal flora balance,intestinal barrier function and immune function in children with acute diarrhea and fever
Objective To observe the clinical efficacy of montmorillonite powder combined with probiotics in children with acute diarrhea and fever,and its effect on intestinal flora balance,intestinal barrier function and immune function.Methods One hundred eighteen children with acute diarrhea and fever admitted to Qiqihar Hospital of traditional Chinese Medicine from October 2021 to October 2023 were randomly divided into two groups by computer-generated random number table:combination group and monotherapy group,59 cases in each group.The monotherapy group was given montelukast on the basis of conventional treatment,1 sachet per day for less than 1 year old,1-2 sachets per day for 1-2 years old,and 2-3 sachets per day for＞2 years old,shaken well with warm water,and the first dose was doubled.In the combination group,Clostridium typhimurium was added on the basis of the single-use group,1 sachet each time,2 times a day,shaken well with cool boiled water and then taken.Both groups were treated for seven days.The recovery speed and therapeutic effect of two groups were compared.The intestinal flora balance,intestinal barrier function and immune function of the two groups before and after treatment were compared.Results The combination group had shorter time of fever reduction,stool improvement,diarrhea cessation and bowel sound recovery than those in the monotherapy group(P＜0.05,0.001).The combination group had higher total effective rate than that in the monotherapy group(88.14％vs 72.88％,P＜0.05).After treatment,the combination group had lower number of enterobacteria than the monotherapy group(P＜0.05),higher number of bifidobacteria,lactobacilli and B/E ratio than the monotherapy group(P＜0.05,0.001).After treatment,the combination group had lower levels of diamine oxidase(DAO),lipopolysaccharide binding protein(LBP)and D-lactic acid than the monotherapy group(P＜0.001).After treatment,the combination group had higher percentage of peripheral blood CD4+T lymphocytes and CD4+/CD8+than those in the monotherapy group(P＜0.001),lower percentage of CD8+T lymphocytes than the monotherapy group(P＜0.001).No obvious adverse reactions were observed in both groups.Conclusion Montmorillonite powder combined with probiotics can promote the recovery of children with acute diarrhea and fever,improve the therapeutic effect,intestinal flora balance,intestinal barrier function and immune function,and have high safety.
NETL
NSTL
万方数据
