Research progress on chemical composition and pharmacological effects of Dendrobium nobile with predictive analysis of quality markers(Q-Marker)
Dendrobium nobile is a traditional Chinese herbal medicine,which has the effects of nourishing the stomach,nourishing yin and clearing heat,and the establishment of its quality standards has always been a hot research issue.In this paper,the research status of the pharmacodynamic relationship of D.nobile is reviewed from the aspects of chemical composition and pharmacological effects,which mainly contain alkaloids,phenanthrene,bibenzyls,sesquiterpenoids,polysaccharides and other compounds,which mainly have various effects such as improving glucose and lipid metabolism,protecting the nervous system,regulating immune response,and anti-tumor.On the basis of the research on the chemical composition and pharmacology of D.nobile and based on the concept of quality marker(Q-Marker)in traditional Chinese medicine,the plant kinship,growth years,chemical composition measurability,different processing methods,traditional efficacy and network pharmacological prediction of D.nobile were analyzed,and the Q-Marker of D.nobile was predicted and analyzed.The pharmacodynamic active ingredients with measurable chemical composition,related efficacy and high component content were selected,and it was preliminarily suggested that dendrobine,mullanin,dendrobol and moscatin should be used as quality markers of D.nobile.To explore the internal correlation between the quality component indexes and pharmacological effects and clinical application of D.nobile hairpin,so as to provide a basis for improving its quality standards.
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