Quantitative value transfer pattern of volatile components in classic formula Danggui Buxue Decoction
Objective The volatile components of the classic formula Danggui Buxue Decoction were detected by GC-MS in tablets,baseline samples,extract powder,concentrates,extracts and granules,to establish a multi-indicator method for the determination of the content of the components and to investigate the transmission law of the quantitative value.Method The volatile components in the baseline sample of Danggui Buxue Decoction were identified by GC-MS,and the attribution of the components was determined.With the help of NIST 20s.lib database and standard comparison,the common components were screened out,and the method for the determination of the content of the common components by GC-MS was established,and the quantitative value transfer patterns were investigated in the tablets-baseline samples,tablets-extracts,extracts-concentrates,concentrates-extract powder,extract powder-granules.Results In the baseline sample of Danggui Buxue Decoction,a total of 10 components were detected,among which two components were from Astragalus membranaceus(Fisch.)Bunge and eight components were from Angelica sinensis,and four common components,including benzoic acid,2-methoxy-4-vinylphenol,ligustilide,and senkynolide H,were screened out.The results showed that these four components were effectively transferred from tablets to granules,and the transfer rates of benzoic acid,2-methoxy-4-vinylphenol and senkynolide H to granules were close to those of the baseline samples,whereas ligustilide was more lost in the concentration and spray-drying processes,resulting in a larger difference in the transfer rates.Conclusion The transfer pattern of different volatile components from slices to granules was inconsistent,and it is necessary to prefer suitable production processes to retain the volatile components and select reasonable evaluation indexes for quality control.
classical formulaGC-MSDanggui Buxue Decoctionquantitative value transferbenzoic acid2-methoxy-4-vinylphenolligustilidesenkynolide H
NETL
NSTL
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