Effectiveness and safety of induction of general anesthesia with ciprofol for burn scab excision and skin grafting surgery:A randomized controlled trial
Objective To observe and analyze the effectiveness and safety of Ciprofol in general anesthesia induction during bum debridement and skin grafting surgery.Method From March 2021 to June 2023,216 adult patients(139 males and 77 females,aged 18-59,with a BMI of 19.6-29.2 kg·m-2)who underwent burn scab excision and skin grafting surgery and met the inclusion criteria were selected from the Burn Surgery Department of Nankai University Affiliated Hospital(Tianjin Fourth Hospital).They were randomly divided into an observation group(111 cases)and a control group(105 cases)using a random number table method.Anesthesia induction:the observation group received 0.4 mg·kg-1 of Ciprofol,while the control group received 2.0 mg·kg-1 of Propofol,The remaining inducing drugs remain consistent.Observe and compare the mean arterial pressure(MAP),heart rate(HR),bispectral index(BIS),respiratory rate(RR),sedation success time,disappearance time of eyelash reflex,injection pain,hypotension,bradycardia,and other adverse reactions between two groups of patients at various time points upon admission to the operating room(T0),completion of propofol/propofol injection(Tl),intubation completion(T2),10 minutes after intubation(T3),and scab removal(T4).Results The difference in baseline data between the two groups was not statistically significant.Compared with the control group,the observation group had higher MAP and HR,and lower BIS at T1 and T2(P＜0.05);The RR of observation group T1 was higher(P＜0.05);The observation group had a shorter time for successful sedation and disappearance of eyelash reflex(P＜0.05);The incidence of injection pain was lower in the observation group(P＜0.05).Conclusion Ciprofol has good sedative effect.Compared with Propofol,Ciprofol is more stable after general anesthesia induction in burn debridement and skin grafting surgery,with fewer adverse reactions such as injection pain,which is worthy of clinical application.
burn patientsscab cutting and skin grafting surgeryCiprofolPropofolinduction of general anesthesiasedative effect
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