Evaluation of therapeutic effect and safety of bronchoscopic alveolar lavage combined with acetylcysteine alveolar lavage on pulmonary consolidation and atelectasis in children
Objective To analyze and evaluate the therapeutic efficacy and safety of alveolar lavage with acetylcysteine(NAC)combined with bronchoscopic alveolar lavage in children with pulmonary solid changes and pulmonary atelectasis.Methods A total of 146 children with pulmonary solid changes and pulmonary atelectasis were selected as study subjects and divided into study group(48 cases,treated with NAC alveolar lavage combined with bronchoscopic alveolar lavage)and control group(98 cases,treated with bronchoscopic alveolar lavage).The therapeutic efficacy and safety of the children in two groups were compared and analyzed.Results The efficacy of the children in study group was better than that of control group(P＜0.05).The disappearance time of lung rales,temperature recovery time and hospitalization time of the children in the study group were shorter than those in control group,and the differences were statistically significant(P＜0.001).The differences in laboratory indexes,arterial blood gas indexes,pulmonary function indexes,and OI before treatment were not statistically significant between two groups.After lavage treatment,the WBC,CRP,PCT level,and PaCO2 level of the children in two groups were lower than those before treatment,and PaO2,SaO2,FEV1,FCV,FEV1/PVC,and OI levels were all higher than before treatment,and the differences between the same groups before and after treatment were statistically significant(P＜0.001).The WBC,CRP,PCT,and PaCO2 levels of the children in study group were lower than those of control group,and the levels of PaO2,SaO2,FEV1,FCV,FEV1/PVC,and OI were higher than those of control group,with statistically significant differences between both groups(P＜0.001).The levels of WBC,CRP,PCT,and PaCO2 were lower than those of control group after treatment.The differences were statistically significant(P＜0.001).The differences in serum SP-A levels and oxidative stress indicators before treatment were not statistically significant between two groups.After lavage treatment,serum SP-A,SOD,and GSH-PX levels of two groups were higher than before treatment,and serum MDA levels were lower than before treatment,and the differences between the same groups before and after treatment were statistically significant(P＜0.001).Serum SP-A,SOD,and GSH-PX levels of the children in study group were higher than before treatment,and serum MDA levels decreased compared to the pre-treatment period,and the differences between the same groups before and after treatment were statistically significant(P＜0.001).Serum SP-A,SOD and GSH-PX levels of children in study group were higher than those of control group,and serum MDA levels were lower than those of control group,and the differences between two groups were statistically significant(P＜0.001).The incidence of adverse reactions in two groups was not statistically significant.Conclusion For children with pulmonary solid lesions and pulmonary atelectasis,the combined use of NAC alveolar lavage treatment in bronchoscopic alveolar lavage treatment can enhance clinical efficacy,significantly alleviate the level of inflammatory response and oxidative stress in children,improve lung function and arterial blood gas index,enhance the level of tissue oxygenation,and promote the restoration of the compliance of the lung tissues,and will not increase the adverse reactions of the treatment.
NETL
NSTL
万方数据
