Meta-analysis of effect of Wenxin Granule on heart structural remodeling and inflammatory markers in patients with atrial fibrillation
Objective To evaluate the effects of Wenxin Granule on structural remodeling and inflammatory markers in patients with atrial fibrillation(AF)by Meta-analysis.Methods PubMed,Embase,Cochrane Library,Web of Science,China National Knowledge Infrastructure(CNKI),Wanfang Database,SinoMed,VIP and China Biology Medicine disc(CBM)were searched for randomized controlled trials(RCTs)of Wenxin Granule in treatment of AF.Excel was used to input the basic information of the article.RevMan 5.4 was used for quality assessment,heterogeneity test and forest map drawing.StataMP 17.0 was used for funnel plot and Egger test.Results A total of 39 RCTs involving 4 211 participants were included.Results of Meta-analysis showed that:Wenxin Granule could improve left ventricular ejection fraction(LVEF,MD=6.01,95％CI[5.03,6.99],P＜0.000 01),reduce left ventricular end-diastolic diameter(LVEDd,MD=-6.35,95％CI[-7.66,-5.04],P＜0.000 01),left ventricular end-systolic diameter(LVESd,MD=-4.35,95％CI[-4.80,-3.90,P＜0.000 01),left atrial diameter(LAd,MD=-3.63,95％CI[-5.43,-1.83],P＜0.000 1),hypersensitive C-reactive protein(hs-CRP,MD=-2.28,95％CI[-3.07,-1.48],P＜0.000 01),C-reactive protein(CRP,MD=-5.71,95％CI[-6.62,-4.79],P＜0.000 01),interleukin-6(IL-6,MD=-10.37,95％CI[-17.00,-3.74],P=0.002),matrix metalloprotein-9(MMP-9,MD=-23.27,P＜0.000 01),95％CI[-26.42,-20.11],P＜0.000 01),matrix metalloprotein-2(MMP-2,MD=-55.85,95％CI[-90.44,-21.27],P=0.002)in AF patients,the difference was statistically significant.The incidence of adverse reactions in the experimental group was lower than that in the control group(RR=0.74,95％CI[0.59,0.93],P=0.009),the difference was statistically significant.Conclusion Wenxin Granule can alleviate structural remodeling and reduce inflammatory markers in patients with atrial fibrillation with good safety.
NETL
NSTL
万方数据
