Research progress of active components of Chinese materia medica regulating immune cells against lung cancer
Lung cancer is the most common malignancy of respiratory tract in the world.Due to its high morbidity and mortality,it has seriously harmed human physical and mental health.Chinese materia medica has a long history in the comprehensive treatment of anti-lung cancer,with outstanding advantages and good curative effect,and most of the active ingredients of Chinese materia medica have good anti-lung cancer effects.Studies have found that some active ingredients of Chinese medicine can regulate immune cells such as macrophages,natural killer cells,myelocyte suppressor cells,T cells,regulatory T cells and dendritic cells in the immune microenvironment of lung cancer by targeting lung cancer signaling pathway,improve the immune microenvironment of lung cancer tumor,improve the function and activity of immune cells,and enhance the immune function of the body.Reverse the immune suppression of the body,so as to play the role of anti-lung cancer treatment.In this paper,through collecting the relevant literatures of Chinese materia medica active ingredients(epimedium polysaccharide,tanshinone Ⅰ,astragaloside Ⅳ,mongoin,ginsenoside,diosgenin,curcumin,tanshinone ⅡA,rhododendron,astragalus polysaccharide,astragalus polysaccharide,Rhodiola rosea glycosides,Ganoderma lucidum polysaccharides,resveratrol,et al)in anti-lung cancer treatment at home and abroad in recent years,the regulation of immune cells by Chinese materia medica active ingredients and the specific mechanism of their anti-lung cancer effects were discussed,in order to provide a new theoretical basis for the research and development of related new clinical anti-lung cancer drugs.
active ingredients of Chinese materia medicaimmune cellslung cancerepimedium polysaccharideastragaloside Ⅳtanshinone ⅡAcurcuminresveratrol
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